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Lyrica (pregabalin) blocks calcium channels in the central nervous system and peripheral nerves. It is used to control seizures and also painful peripheral neuropathy such as that seen in some diabetics, some people after an outbreak of shingles (also known as post-herpetic neuralgia), or in nerve compression syndromes such as spinal stenosis and herniated lumbar discs. It has been found to be helpful in a significant percentage of people with fibromyalgia. Neurontin (gabapentin) is structurally similar to Lyrica and has a similar mechanism of action. Both are structurally related to the neural transmitter GABA, but neither drug seems to affect GABA uptake, release, or degradation. Both drugs can cause sleepiness, so it is good to start with a relatively low dose and gradually build up therapeutic levels. Likewise, one should taper off both drugs over a week or two to prevent seizures or other withdrawal symptoms.

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